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Volume 4 Issue 4

 

 

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4-Nitrophthalic acid - catalyzed Biginelli reaction: One-pot synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones/thiones under solvent free conditions
Dr. Rangappa S. Keri || Dr. Siddappa A. Patil

Abstract: New organic reactions allow chemical transformations which were previously not possible. Therefore, new reactions are important contributions to the progress in the field of organic synthesis. A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives from aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using 4-Nitrophthalic acid as a catalyst under solvent free condition is described. Taking into account of environmental and economical considerations, the protocol presented here has the merits of environmentally benign, simple operation, convenient work-up, short time, good yields, the avoidance of the organic solvent and inexpensive catalyst. The synthesized compounds were characterized by IR, 1H, 13C NMR, MS and elemental analysis.
Keywords: Biginelli reaction; Synthesis; Solvent free; 3, 4-Dihydropyrimidin-2(1H)-ones; Catalyst.
Refer this Research Paper(copy & paste below code)
Dr. Rangappa S. Keri, Dr. Siddappa A. Patil - 4-Nitrophthalic acid - catalyzed Biginelli reaction: One-pot synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones/thiones under solvent free conditions - published at: "International Journal of Engineering Inventions, Volume 4, Issue 4, September 2014 Edition".
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